A systems radiation biology approach to unravel the role of chronic low-dose-rate gamma-irradiation in inducing premature senescence in endothelial cells.

Gabriele BabiniGiorgio BaioccoSofia BarbieriJacopo MoriniTraimate SangsuwanSiamak HaghdoostRamesh YentrapalliOmid AzimzadehCharlotte RomboutsAn AertsRoel QuintensTeni EbrahimianMohammed Abderrafi BenotmaneRaghda RamadanSarah BaatoutSoile TapioMats Harms-RingdahlAndrea Ottolenghi

Published in: PloS one (2022)

This study was conducted integrating different datasets, focusing on their temporal dynamics, and using a systems biology approach. Results of our analysis highlight that different dose rates have different effects in inducing premature senescence, and that the total cumulative absorbed dose also plays an important role in accelerating endothelial cell senescence.

Keyphrases

endothelial cells
low dose
high glucose
vascular endothelial growth factor
dna damage
radiation induced
radiation therapy
drug induced
data analysis