The effect of antenatal depression and antidepressant treatment on placental tissue: a protein-validated gene expression study.

Åsa EdvinssonCharlotte HellgrenTheodora Kunovac KallakHelena ÅkerudAlkistis SkalkidouElisabet Stener-VictorinRomina FornesOlav SpigsetSusanne LagerJocelien OlivierInger Sundström-Poromaa

Published in: BMC pregnancy and childbirth (2019)

The differentially expressed HTR1A, both at the gene and the protein level that was revealed in this study, suggests the involvement of HTR1A in the effect of antenatal depression on biological mechanisms in the placenta. More research is needed to elucidate the role of depression and antidepressant treatment on the placenta, and, further, the effect on the fetus.

Keyphrases

gene expression
depressive symptoms
pregnant women
major depressive disorder
sleep quality
dna methylation
preterm birth
protein protein
physical activity
combination therapy
transcription factor