Safety and virologic impact of haploidentical NK cells plus IL-2 or N-803 in HIV infection.
Jeffrey S MillerJoshua RheinZachary B DavisSarah CooleyDavid McKennaJodi AndersonKevin Escandón-VargasGarritt WiekingJarrett ReichelAnn ThorkelsonSiri JorstadJeffrey T SafritPatrick Soon-ShiongGregory J BeilmanJeffrey G ChipmanTimothy W SchackerPublished in: The Journal of infectious diseases (2024)
There was a moderate decrease in HIV-producing cells in lymph nodes. Further studies are warranted to determine the impact of healthy NK cells on HIV reservoirs and if restoring NK-cell function could be part of an HIV cure strategy.
Keyphrases
- nk cells
- antiretroviral therapy
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv testing
- hiv aids
- lymph node
- hepatitis c virus
- men who have sex with men
- induced apoptosis
- bone marrow
- oxidative stress
- cell cycle arrest
- signaling pathway
- early stage
- peripheral blood
- cell proliferation
- cord blood
- locally advanced
- high dose