Cell specific interaction of pasireotide: review of preclinical studies in somatotroph and corticotroph pituitary cells.

Federico GattoMarica ArvigoJessica AmarùClaudia CampanaFrancesco CocchiaraGiulia GrazianiEleonora BruzzoneMassimo GiustiMara BoschettiDiego Ferone

Published in: Pituitary (2019)

The analysis of preclinical studies carried out in somatotroph and corticoph adenomas points out that pasireotide shows a cell-specific activity, exerting its biological effects via different SSTs in the different adenoma histotypes.

Keyphrases

cell therapy
single cell
induced apoptosis
stem cells
cell cycle arrest
oxidative stress
mesenchymal stem cells
signaling pathway
endoplasmic reticulum stress
pi k akt