Hua-Shi-Bai-Du decoction inactivates NLRP3 inflammasome through inhibiting PDE4B in macrophages and ameliorates mouse acute lung injury.

Ximeng LiWenjing LiChenchen ZangJingjing YanMin CaiZhuangzhuang LiuRunlan CaiYuan GaoYun Qi

Published in: Phytomedicine : international journal of phytotherapy and phytopharmacology (2024)

HSBD suppresses the activation of NLRP3 inflammasome by inhibiting PDE4B activity to counteract the decrease of intracellular cAMP, thereby blocking ASC oligomerization in macrophages. Our findings may provide new insight into the clinical effets of HSBD for the treatment of COVID-19.

Keyphrases

nlrp inflammasome
signaling pathway
coronavirus disease
sars cov
lipopolysaccharide induced
lps induced
mouse model
reactive oxygen species
inflammatory response