Phonozen-mediated photodynamic therapy comparing two wavelengths in a mouse model of peritoneal carcinomatosis.

Hyoung Il Kim Sung-Ho Lee Su-Jin Shin Jong-Hyun Park Jae Eun Yu Sang Won Lee Seung Hee Yang Layla Pires Brian C Wilson

Published in: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology (2023)

Phonozen-mediated PDT results in significant cytotoxicity in vitro as well as tumor necrosis and prolonged survival in vivo following intraperitoneal light irradiation. Blue light was more photocytotoxic than red in vitro and had marginally higher efficacy in vivo.

Keyphrases

photodynamic therapy
mouse model
fluorescence imaging
free survival