Bimetallic Organic Frameworks of High Piezo-Voltage for Sono-Piezo Dynamic Therapy.

Piezoelectric materials produce charges to directly act on cancer medium or promote reactive oxygen species (ROS) generation for novel tumor therapy triggered by sonography. Currently, piezoelectric sonosensitizers are mainly used to catalyze ROS generation by band-tilting effect for sonodynamic therapy. However, it remains a challenge for piezoelectric sonosensitizers to produce high piezo-voltages to overcome the band-gap barrier for direct charge generation. Herein, the Mn-Ti bimetallic organic framework tetragonal nanosheets (MT-MOF TNS) are designed to produce high piezo-voltages for novel sono-piezo dynamic therapy (SPDT) with remarkable antitumor efficacy in vitro and in vivo. MT-MOF TNS content non-centrosymmetric secondary building units of Mn-Ti-oxo cyclic octamers with charge heterogeneous components for piezoelectricity. MT-MOF TNS promote strong sono-cavitation to insitu induce piezoelectric effect with a high sono-piezo (SP) voltage (2.9 V) to directly excite charges, which is validated by sono-piezo-excited luminescence spectrometry. The SP voltage and charges depolarize the mitochondrial and plasma membrane potentials, and cause ROS overproduction and serious tumor cell damage. Importantly, MT-MOF TNS can be decorated with targeting molecules and chemotherapeutics for more severe tumor regression by combining SPDT with chemodynamic therapy and chemotherapy. This report develops a fascinating MT-MOF piezoelectric nano-semiconductor and provides an efficient SPDT strategy for tumor treatment. This article is protected by copyright. All rights reserved.