Aberrant Thyroid-Stimulating Hormone Receptor Signaling Increases VEGF-A and CXCL8 Secretion of Thyroid Cancer Cells, Contributing to Angiogenesis and Tumor Growth.

Young Shin SongMin Joo KimHyun Jin SunHwan Hee KimHyo Shik ShinYoung A KimByung-Chul OhSun Wook Cho Young Joo Park

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

Aberrant TSH receptor signaling modulates tumor angiogenesis by stimulating VEGF-A and CXCL8 secretion from PDTC cells and enhances tumor growth; thus, TSH suppression is beneficial for treating PDTCs.

Keyphrases

vascular endothelial growth factor
endothelial cells
induced apoptosis
cell cycle arrest
oxidative stress
pi k akt