Anti-cancer effect of fenbendazole-incorporated PLGA nanoparticles in ovarian cancer.

Chi-Son Chang Ji-Yoon Ryu Young-Jae Cho Young-Jae Cho Jung-Joo Choi Jae Ryoung Hwang Ju-Yeon Choi Joseph J Noh Chan Mi Lee Ji Eun Won Hee Dong Han Jeong-Won Lee

Published in: Journal of gynecologic oncology (2023)

FZ-incorporated PLGA nanoparticles exerted significant anti-cancer effects in EOC cells and xenograft models including PDX. These results warrant further investigation in clinical trials.

Keyphrases

clinical trial
drug delivery
induced apoptosis
drug release
cell cycle arrest
bone regeneration
oxidative stress
endoplasmic reticulum stress
open label
signaling pathway