Pharmacogenetic study of phosphatase and tensin homolog polymorphism (rs701848) in childhood epilepsy: relation to circulating Wnt signaling.

Mohammed H HassanAhmed Y NassarAbdel-Raheim M A MekiShimaa A NasserAli Helmi BakriEman Radwan

Published in: Neurological research (2023)

We originally found a strong association between PTEN rs701848 T/C and childhood epilepsy, in particular pharmacoresistant type. Serum Wnt3a levels increased in epilepsy, but were not significantly different between different alleles of PTEN. In pharmaco-responsive children Wnt3a levels differed significantly between the different PTEN genotypes. Antiepileptics may affect Wnt3a levels.

Keyphrases

cell proliferation
stem cells
pi k akt
young adults
signaling pathway
childhood cancer