A Surface Matrix of Au NPs Decorated Graphdiyne for Multifunctional Laser Desorption/Ionization Mass Spectrometry.
Jingxuan PeiYanfang ZhaoShuting ZhangXiang YuZhenfei TianYibo SunShiqing MaRu-Song ZhaoJianping MengXiangfeng ChenFang ChenPublished in: ACS applied materials & interfaces (2023)
The development of the valid strategy to enhance laser desorption/ionization efficiency gives rise to widespread concern in surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) technology. Herein, a hybrid of Au NP-decorated graphdiyne (Au/GDY) was fabricated and employed as the SALDI-MS matrix for the first time, and a mechanism based on photothermal and photochemical energy conversions was proposed to understand LDI processes. Given theoretical simulations and microstructure characterizations, it was revealed that the formation of a coupled thermal field and internal electric field endow the as-prepared Au/GDY matrix with superior desorption and ionization efficiency, respectively. Moreover, laser-induced matrix ablation introduced strain and defect level into the Au/GDY hybrid, suppressing the recombination of charge carriers and thereby facilitating analyte ionization. The optimized Au/GDY matrix allowed for reliable detection of trace sulfacetamide and visualization of exogenous/endogenous components in biological tissues. This work offers an integrated solution to promote LDI efficiency based on collaborative photothermal conversion and internal electric field, and may inspire the design of novel semiconductor-based surface matrices.
Keyphrases
- reduced graphene oxide
- mass spectrometry
- sensitive detection
- gas chromatography
- liquid chromatography
- gold nanoparticles
- quantum dots
- drug delivery
- cancer therapy
- multiple sclerosis
- visible light
- photodynamic therapy
- high performance liquid chromatography
- high resolution
- ms ms
- capillary electrophoresis
- loop mediated isothermal amplification
- gene expression
- signaling pathway
- dna damage
- room temperature
- molecular dynamics
- heavy metals
- highly efficient