MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer.
Tong NiuWeiwei ZhangWei XiaoPublished in: Cancer cell international (2021)
Breast cancer is the most common cancer among women and accounts for 30% of all female malignancies worldwide. Breast cancer stem cells (BCSCs) are a small population of breast cancer cells that exhibit multiple characteristics including differentiation capacity, self-renewal and therapeutic resistance. Recently, BCSCs have attracted attention due to their modulation of breast tumor behaviors and drug resistance. miRNAs are small noncoding mRNAs involved in virtually all biological processes, including stem cell development, maintenance and differentiation. In breast cancer, miRNAs appear to be multi-faceted since they can act as either suppressors or oncogenes to regulate breast cancer progression. This review summarizes the critical roles of miRNAs in regulating multiple signaling pathways such as Wnt/β-catenin, Notch, PI3K/AKT/mTOR, BMI-1 and STAT3 that are important for the BCSC maintenance.
Keyphrases
- cancer stem cells
- stem cells
- cell proliferation
- breast cancer cells
- signaling pathway
- epithelial mesenchymal transition
- body mass index
- squamous cell carcinoma
- working memory
- polycystic ovary syndrome
- pregnant women
- type diabetes
- adipose tissue
- physical activity
- skeletal muscle
- oxidative stress
- mesenchymal stem cells
- papillary thyroid
- young adults
- lymph node metastasis