Reversible Thermoelectric Regulation of Electromagnetic and Chemical Enhancement for Rapid SERS Detection.
Chao ZhangJibing TanBaoqiang DuChang JiZhiyang PeiMingrui ShaoShouzhen JiangXiaofei ZhaoJing YuBaoyuan ManZhen LiKaichen XuPublished in: ACS applied materials & interfaces (2024)
Actively controlling surface-enhanced Raman scattering (SERS) performance plays a vital role in highly sensitive detection or in situ monitoring. Nevertheless, it is still challenging to achieve further modulation of electromagnetic enhancement and chemical enhancement simultaneously in SERS detection. In this study, a silver nanocavity structure with graphene as a spacer layer is coupled with thermoelectric semiconductor P-type gallium nitride (GaN) to form an electric-field-induced SERS (E-SERS) for dual enhancement. After applying the electric field, the intensity of SERS signals is further enhanced by over 10 times. The thermoelectric field enables fast and reproducible doping of graphene, thereby modulating its Fermi level over a wide range. The thermoelectric field also regulates the position of the plasmon resonance peak of the silver nanocavity structure, rendering synchronous dual electromagnetic and chemical regulation. Additionally, the method enables the trace detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A detailed theoretical analysis is performed based on the experimental results and finite-element calculations, paving the way for the fabrication of high-efficient E-SERS substrates.
Keyphrases
- sensitive detection
- loop mediated isothermal amplification
- gold nanoparticles
- quantum dots
- sars cov
- respiratory syndrome coronavirus
- label free
- raman spectroscopy
- energy transfer
- room temperature
- finite element
- signaling pathway
- oxidative stress
- density functional theory
- molecular dynamics simulations
- molecular dynamics
- real time pcr
- risk assessment
- walled carbon nanotubes
- carbon nanotubes
- ionic liquid
- tissue engineering
- endothelial cells