Determining mutational burden and signature using RNA-seq from tumor-only samples.
Erik JessenYuanhang LiuJaime DavilaJean-Pierre KocherChen WangPublished in: BMC medical genomics (2021)
Taken together, our work provides a novel method to detect RNA-seq derived mutational signatures with effective procedures to remove likely germline variants. It can leads to accurate classification of underlying driving mechanisms of DNA damage deficiency.