Pulsatility protects the endothelial glycocalyx during extracorporeal membrane oxygenation.

Yu ZhangJianfeng ZengXiaoqian HeWeidong CaoXiaopeng PengGuanhua Li

Published in: Microcirculation (New York, N.Y. : 1994) (2021)

The maintenance of the PWSS by pulsatility during ECMO possesses beneficial effects on glycocalyx integrity. Moreover, pulsatility prevents EndMT in endothelial cells, and low pulsatility exhibits the best protective effects. The augmentation of pulsatility may be a plausible future direction to improve the clinical outcome in ECMO.

Keyphrases

extracorporeal membrane oxygenation
acute respiratory distress syndrome
endothelial cells
respiratory failure
mechanical ventilation
intensive care unit
soft tissue
high glucose