Exposure to recurrent hypoglycemia alters hippocampal metabolism in treated streptozotocin-induced diabetic rats.

Neelesh DewanVibha ShuklaAshish K RehniKevin B KoronowskiKyle D KlingbeilHolly Stradecki-CohanTimothy J GarrettTatjana RundekMiguel A Perez-PinzonKunjan R Dave

Published in: CNS neuroscience & therapeutics (2019)

Our results demonstrate that the exposure to RH leads to metabolomics alterations in the hippocampus of insulin-treated streptozotocin-diabetic rats. Understanding how RH affects hippocampal metabolism may help attenuate the adverse effects of RH on hippocampal functions.

Keyphrases

diabetic rats
oxidative stress
cerebral ischemia
type diabetes
temporal lobe epilepsy
glycemic control
subarachnoid hemorrhage
blood brain barrier
mass spectrometry
brain injury
emergency department
newly diagnosed
adipose tissue
weight loss
prefrontal cortex