Non-response to rituximab therapy in rheumatoid arthritis is associated with incomplete disruption of the B cell receptor repertoire.
Sabrina PollastroPaul L KlarenbeekMarieke E DoorenspleetBarbera D C van SchaikRebecca E E EsveldtRogier M ThurlingsMaria J H BoumansDanielle M GerlagPaul P TakKoen VosFrank BaasAntoine H C van KampenNiek de VriesPublished in: Annals of the rheumatic diseases (2019)
Significant changes in BCR clonality are observed in peripheral blood of patients 4 weeks after rituximab treatment, while changes in synovial tissue were observed at later time points. Incomplete depletion of the dominant baseline peripheral blood BCR repertoire in the first month of treatment might predict clinical non-response at 3 months.
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