Login / Signup

BMP9-induced vascular normalisation improves the efficacy of immunotherapy against hepatitis B virus-associated hepatocellular carcinoma.

Yulong HanQiuzhong PanZhixing GuoYufei DuYaojun ZhangYingying LiuJingjing ZhaoJinfeng XuJieying YangDijun OuyangYan TangQijing WangYongqiang LiJia HeMengjuan YangHao ChenChaopin YangXinyi YangJinqi YouYuanyuan ChenMinghao RenYao ZhuJian-Chuan XiaTong Xiang
Published in: Clinical and translational medicine (2023)
HBV-induced BMP9 downregulation causes vascular abnormalities that inhibit intra-tumoural cytotoxic lymphocyte infiltration, providing a rationale for developing and combining immunotherapy with BMP9-based therapy to treat HBV-associated HCC.
Keyphrases
  • hepatitis b virus
  • mesenchymal stem cells
  • liver failure
  • high glucose
  • diabetic rats
  • bone regeneration
  • clinical trial
  • cell proliferation
  • drug induced
  • oxidative stress
  • bone marrow
  • stress induced