CISD2 promotes lung squamous carcinoma cell migration and invasion via the TGF-β1-induced Smad2/3 signaling pathway.

Jingjing ZhangLifang PanShirong ZhangYuhong YangJiafeng LiangShenglin MaQiong Wu

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2023)

In conclusion, our research illustrates that CISD2 is highly expressed in LUSC and may facilitate LUSC proliferation and metastasis. Thus, CISD2 may serve as an independent prognostic marker and possible treatment target for LUSC.

Keyphrases

signaling pathway
transforming growth factor
epithelial mesenchymal transition
single cell
pi k akt
high grade
diabetic rats
cell therapy
induced apoptosis
low grade
oxidative stress
replacement therapy
combination therapy
endoplasmic reticulum stress
stress induced