Sub-Anaesthetic Dose of Propofol Attenuates Mechanical Allodynia in Chronic Post-Ischaemic Pain via Regulation of PTEN/PI3K/IL-6 Signalling.

Siu Yi Doreen LeungFei MengJingjing LiuAijia Jessica LiuHei Lui Lhotse NgChi Wai CheungSau Ching Stanley Wong

Published in: Molecular pain (2023)

Sub-anaesthetic dose of propofol administration resulted in the activation of PTEN, inhibition of both PI3K/AKT signalling and IL-6 production in the spinal cord, which dramatically reduced CPIP-induced pain. Our findings lay the foundation in using propofol for the treatment of CRPS with great therapeutic implications.

Keyphrases

pi k akt
neuropathic pain
spinal cord
signaling pathway
chronic pain
cell proliferation
cell cycle arrest
pain management
spinal cord injury
high glucose
drug induced
diabetic rats
oxidative stress
endothelial cells
smoking cessation