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An anti-inflammatory isoflavone from soybean inoculated with a marine fungus Aspergillus terreus C23-3.

Jing-Ming YangYa-Yue LiuWen-Cong YangXiao-Xiang MaYing-Ying NieEvgenia GlukhovLena GerwickWilliam H GerwickXiao-Ling LeiYi Zhang
Published in: Bioscience, biotechnology, and biochemistry (2020)
A new isoflavone derivative compound 1 (psoralenone) was isolated from soybean inoculated with a marine fungus Aspergillus terreus C23-3, together with seven known compounds including isoflavones 2-6, butyrolactone I (7) and blumenol A (8). Their structures were elucidated by MS, NMR, and ECD. Psoralenone displayed moderate in vitro anti-inflammatory activity in the LPS-induced RAW264.7 cell model. Compound 2 (genistein) showed moderate acetylcholinesterase (AChE) inhibitory activity whereas compounds 2, 5 (biochanin A), 6 (psoralenol), and 7 exhibited potent larvicidal activity against brine shrimp. Compounds 3 (daidzein), 4 (4'-hydroxy-6,7-dimethoxyisoflavone), and 5-7 showed broad-spectrum anti-microbial activity, and compound 7 also showed moderate 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity.
Keyphrases
  • lps induced
  • anti inflammatory
  • high intensity
  • inflammatory response
  • high resolution
  • magnetic resonance
  • multiple sclerosis
  • single cell
  • microbial community
  • bone marrow
  • aedes aegypti