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Z -selective radical difunctionalization of aromatic alkynes: synthesis of multi-substituted triarylethenes.

Xinxin WangJie WangMeishan JiXin-Xin WuChen Zhu
Published in: Chemical communications (Cambridge, England) (2024)
An efficient method for the radical difunctionalization of aromatic alkynes has been developed, resulting in the synthesis of a range of valuable triarylethenes. This approach utilizes strategically designed aryldiazonium salts with tertiary alcohol substitution as bifunctional reagents, along with cost-effective cuprous chloride as a catalyst. The method demonstrates remarkable Z -selectivity and is capable of gram-scale preparation. Additionally, a novel spin-trapping reagent has been developed based on the synthesized product.
Keyphrases
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