Heterolactone and Heterolactams A-M, Verticillane Diterpenoids with Anti-Inflammatory and Hepatoprotective Activities from the Soft Coral Heteroxenia ghardaqensis .

Xiao HanKun LiuAnran FuZongchen MaZhe WangXiaolei LiXuli TangDahai ZhangGuo-Qiang Li
Published in: Journal of natural products (2023)
Fourteen new verticillane diterpenoids, heterolactone ( 1 ) and heterolactams A-M ( 2 - 14 ), were isolated from the soft coral Heteroxenia ghardaqensis . They structurally share the same 6/12 bicyclic carbon skeleton that is not commonly encountered in marine organisms. The structures, including the absolute configurations, were determined by extensive spectroscopic analysis, single-crystal X-ray diffraction analysis, calculated ECD spectra, and DP4+ probability analyses. Compounds 5 , 8 , and 9 showed anti-inflammatory activities, and 2 , 8 , and 12 displayed hepatoprotective activities in zebrafish assays.