Is fibromyalgia associated with a unique cytokine profile? A systematic review and meta-analysis.

Luke Furtado O'MahonyArnav SrivastavaPuja Mehta Coziana Ciurtin

Published in: Rheumatology (Oxford, England) (2021)

We found evidence of significant differences in the peripheral blood cytokine profiles of fibromyalgia patients compared with HC. However, the distinctive profile associated with fibromyalgia includes both pro-inflammatory (TNF-α, IL-6, IL-8) and anti-inflammatory (IL-10) cytokines in pooled analysis, as well as chemokine (eotaxin) signatures. Further research is required to elucidate the role of cytokines in fibromyalgia.

Keyphrases

peripheral blood
end stage renal disease
anti inflammatory
ejection fraction
newly diagnosed
chronic kidney disease
rheumatoid arthritis
prognostic factors
patient reported outcomes