Acute posterior multifocal placoid pigment epitheliopathy resembling multiple sclerosis.
Sahla El MahdaouiAsher Lou IsenbergKlaus HansenAnnika Reynberg LangkildeSteffen HamannJeppe Romme ChristensenPublished in: Practical neurology (2022)
A 23-year-old man presented with right eye blurred vision; he was diagnosed with acute posterior multifocal placoid pigment epitheliopathy (APMPPE), and his symptoms resolved with prednisolone. Two months later, he developed a right arm weakness that resolved after 3 weeks. MR scan of brain identified changes suggesting multiple sclerosis, with four hyperintense FLAIR lesions; there was contrast enhancement of two lesions and no diffusion restriction. Cerebrospinal fluid showed mononuclear pleocytosis. We eventually diagnosed these as APMPPE-associated CNS lesions. APMPPE is a rare inflammatory chorioretinopathy that rarely can resemble multiple sclerosis clinically and radiologically.
Keyphrases
- multiple sclerosis
- white matter
- liver failure
- cerebrospinal fluid
- respiratory failure
- magnetic resonance
- drug induced
- aortic dissection
- computed tomography
- contrast enhanced
- blood brain barrier
- hepatitis b virus
- magnetic resonance imaging
- resting state
- depressive symptoms
- sleep quality
- mechanical ventilation
- functional connectivity