SMARCE1 regulates metastatic potential of breast cancer cells through the HIF1A/PTK2 pathway.

Aarti SethuramanMartin BrownTiffany N SeagrovesZhao-Hui WuLawrence M PfefferMeiyun Fan

Published in: Breast cancer research : BCR (2016)

SMARCE1 plays an essential role in breast cancer metastasis by protecting cells against anoikis through the HIF1A/PTK2 pathway. SMARCE1-mediated PTK2 activation likely plays a key role in promoting metastasis of basal-like and luminal B subtype of breast tumors.

Keyphrases

breast cancer cells
induced apoptosis
squamous cell carcinoma
cell cycle arrest
small cell lung cancer
endothelial cells
cell death
young adults