An organoid model of colorectal circulating tumor cells with stem cell features, hybrid EMT state and distinctive therapy response profile.

Maria Laura De AngelisFederica FrancescangeliChiara NicolazzoMichele SignoreAlessandro GiulianiLidia ColaceAlessandra BoeValentina MagriMarta BaiocchiAntonio CiardiFrancesco ScarolaMassimo SpadaFilippo La TorrePaola GazzanigaMauro BiffoniRuggero De MariaAnn Zeuner

Published in: Journal of experimental & clinical cancer research : CR (2022)

These results indicate that CTCDOs recapitulate several features of colorectal CTCs and may be used to investigate the features of metastatic CRC cells, to identify new prognostic biomarkers and to devise new potential strategies for metastasis prevention.

Keyphrases

circulating tumor cells
stem cells
induced apoptosis
squamous cell carcinoma
small cell lung cancer
circulating tumor
epithelial mesenchymal transition
cell proliferation
climate change
cell free