Direct Assembly of Polysubstituted Propiolamidinates via Palladium-Catalyzed Multicomponent Reaction of Isocyanides.

A straightforward approach for the assembly of different polysubstituted propiolamidnates via palladium-catalyzed multicomponent reaction of isocyanides, haloalkynes, and amines has been reported in which the C(sp)-C(sp2) and C(sp2)═N bonds were constructed in one pot. This reaction featured in high efficiency, excellent chemoselectivity, and good functional group compatibility. The synthetic utility of this method was also demonstrated.