Dupilumab prevents nasal epithelial function alteration by IL-4 in vitro: Evidence for its efficacy.
Maxime FieuxFlorent CarsuzaaYvan BellangerSophie BartierVirginie FournierJean Claude LecronMatthieu BainaudBruno LouisStéphane TringaliXavier DufourAndré CosteLaure FavotEmilie BequignonPublished in: International forum of allergy & rhinology (2024)
Dupilumab, in vitro, restored epithelial integrity by counteracting the effect of IL-4 on the epithelial barrier (increased epithelial permeability, decreased ciliary beating efficiency, and decreased wound repair rate).
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