Scorpion venom heat-resistant synthesized peptide ameliorates 6-OHDA-induced neurotoxicity and neuroinflammation: likely role of Nav 1.6 inhibition in microglia.
Xiujie LiXuefei WuNa LiDonglai LiAoran SuiKhizar KhanBiying GeSheng LiShao LiJie ZhaoPublished in: British journal of pharmacology (2021)
SVHRSP might inhibit neuroinflammation and protect dopamine neurons via down-regulating microglial Nav 1.6 and subsequently suppressing intracellular Ca2+ accumulation to attenuate the activation of MAPKs signalling pathway in microglia.
Keyphrases
- inflammatory response
- lipopolysaccharide induced
- lps induced
- neuropathic pain
- spinal cord
- traumatic brain injury
- high glucose
- diabetic rats
- cognitive impairment
- cerebral ischemia
- signaling pathway
- heat stress
- uric acid
- drug induced
- metabolic syndrome
- oxidative stress
- reactive oxygen species
- endothelial cells
- blood brain barrier
- subarachnoid hemorrhage