Schwann Cells in Neuromuscular Junction Formation and Maintenance.

Arnab Barik Lei Li Anupama Sathyamurthy Wen-Cheng XiongLin Mei

Published in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2017)

Neuromuscular junctions (NMJs) are critical for survival and daily functioning. Defects in NMJ formation during development or maintenance in adulthood result in debilitating neuromuscular disorders. The role of Schwann cells (SCs) in NMJ formation and maintenance was not well understood. We genetically ablated SCs during development and after NMJ formation to investigate the consequences of the ablation. This study reveals a critical role of SCs in NMJ formation as well as maintenance.

Keyphrases

induced apoptosis
cell cycle arrest
depressive symptoms
cell death
oxidative stress
physical activity
endoplasmic reticulum stress
peripheral nerve
single molecule
radiofrequency ablation