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Evaluating Functional Immunity Following Encapsulated Bacterial Infection and Vaccination.

Zheng Quan TohRachel A HigginsNadia MazarakisElysia AbbottJordan NathanielszAnne BallochKim MulhollandPaul Vincent Licciardi
Published in: Vaccines (2021)
Encapsulated bacteria such as Streptococcus pneumoniae, Haemophilus influenzae type b and Neisseria meningitidis cause significant morbidity and mortality in young children despite the availability of vaccines. Highly specific antibodies are the primary mechanism of protection against invasive disease. Robust and standardised assays that measure functional antibodies are also necessary for vaccine evaluation and allow for the accurate comparison of data between clinical studies. This mini review describes the current state of functional antibody assays and their importance in measuring protective immunity.
Keyphrases
  • high throughput
  • electronic health record
  • big data
  • high resolution
  • machine learning