An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) for the quantification of phenobarbital in human serum and plasma.

Tobias SchierscherLinda SalzmannNeeraj SinghMartina BachmannAnja KobelJanik WildFriederike BaulandAndrea GeistangerLorenz RischChristian GeletnekyChristoph SegerJudith Taibon

Published in: Clinical chemistry and laboratory medicine (2024)

A novel LC-MS/MS-based candidate RMP for the quantification of phenobarbital in human serum and plasma is presented which can be used for the standardization of routine assays and the evaluation of clinically relevant samples.

Keyphrases

liquid chromatography tandem mass spectrometry
simultaneous determination
ms ms
solid phase extraction
clinical practice
high throughput
minimally invasive
gas chromatography
mass spectrometry
high resolution