New insights into the early mechanisms of epileptogenesis in a zebrafish model of Dravet syndrome.
Ettore TiraboschiSilvia MartinaWietske van der EntKamil GrzybKinga GawelMaria Lorena Cordero-MaldonadoSuresh Kumar PoovathingalSarah HeintzSomisetty Venkata SatheeshJarle BrattespeJu XuMaximiliano SusterAlexander SkupinCamila V EsguerraPublished in: Epilepsia (2020)
Our findings provide novel insights into early mechanisms of DS pathogenesis, describe dynamic cell population changes in the scn1labmut/mut brain, and present first-time evidence for potential disease modification by fenfluramine.