No Gastrointestinal Dysmotility in Transgenic Mouse Models of Migraine.

Adam S Sprouse BlumBrigitte LavoieMelody HaagSeamus M MaweElse A TolnerArn M J M van den MaagdenbergShih-Pin ChenKatharina Eikermann-HaerterLouis PtáčekGary M MaweRobert E Shapiro

Published in: Headache (2019)

We detected no evidence of upper gastrointestinal dysmotility in mice that express mutations in genes linked to monogenic migraine-relevant phenotypes. Future studies seeking to understand why humans with migraine experience delayed gastric emptying may benefit from pursuing other modifiers of gastrointestinal motility, such as epigenetic or microbiome-related factors.

Keyphrases

mouse model
dna methylation
gene expression
mental health
genome wide
current status
high fat diet induced
type diabetes
metabolic syndrome
insulin resistance
bioinformatics analysis
wild type