Heparanase as a potential player in SARS-CoV-2 infection and induced coagulopathy.
Safa KinanehIyad KhamaysiTony KarramShadi HamoudPublished in: Bioscience reports (2021)
During the current formidable COVID-19 pandemic, it is appealing to address ideas that may invoke therapeutic interventions. Clotting disorders are well recognized in patients infected with severe acute respiratory syndrome (SARS) caused by a novel coronavirus (SARS-CoV-2), which lead to severe complications that worsen the prognosis in these subjects. Increasing evidence implicate Heparan sulfate proteoglycans (HSPGs) and Heparanase in various diseases and pathologies, including hypercoagulability states. Moreover, HSPGs and Heparanase are involved in several viral infections, in which they enhance cell entry and release of the viruses. Herein we discuss the molecular involvement of HSPGs and heparanase in SARS-CoV-2 infection, namely cell entry and release, and the accompanied coagulopathy complications, which assumedly could be blocked by heparanase inhibitors such as Heparin and Pixatimod.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- end stage renal disease
- single cell
- cell therapy
- chronic kidney disease
- ejection fraction
- physical activity
- prognostic factors
- stem cells
- venous thromboembolism
- drug induced
- oxidative stress
- early onset
- high glucose
- diabetic rats
- growth factor
- case report
- risk assessment
- climate change
- single molecule
- human health