Gene-Environment Interactions Significantly Alter the Obesity Risk of SH2B1 rs7498665 Carriers.

Danyel ChermonRuth Birk

Published in: Journal of obesity & metabolic syndrome (2024)

rs7498665 significantly elevates the risk of obesity. Actionable lifestyle and behavioral factors significantly modulate the rs7498665 genetic predisposition to obesity; PA and moderate wine consumption attenuate the risk, while high stress, EHS, and fasting glucose level increase the obesity risk.

Keyphrases

insulin resistance
metabolic syndrome
weight loss
high fat diet induced
type diabetes
weight gain
adipose tissue
blood glucose
cardiovascular disease
physical activity
body mass index
transcription factor
gene expression
breast cancer risk