GSK-3β inhibitor TDZD-8 reduces neonatal hypoxic-ischemic brain injury in mice.

Sammen HuangHaitao WangEkaterina TurlovaAhmed AbussaudXiang JiLuiz R BrittoSteven P MillerAna MartinezHong-Shuo SunZhong-Ping Feng

Published in: CNS neuroscience & therapeutics (2017)

TDZD-8 has the therapeutic potential for hypoxic-ischemic brain injury in neonates. The neuroprotective effect of TDZD-8 appears to be mediated through its antiapoptotic activity and by reducing astrogliosis.

Keyphrases

brain injury
cerebral ischemia
subarachnoid hemorrhage
signaling pathway
high fat diet induced
pi k akt
low birth weight
metabolic syndrome
cell proliferation