Rheumatoid Factor Recognizes Specific Domains of the IgG Heavy Chain Complexed with HLA Class II Molecules.

Shanshan ZhangHideaki TsujiHui JinKoji KitagoriShuji AkizukiRan NakashimaHajime YoshifujiMasao TanakaHisashi AraseKoichiro OhmuraAkio Morinobu

Published in: Rheumatology (Oxford, England) (2023)

The CH1 domain of IgGH binds to the RA-susceptible HLA-DR molecule and is expressed on the cell surface. RF specifically recognizes the CH3 domain of the IgGH/HLA-DR4 complex.

Keyphrases

cell surface
room temperature
editorial comment
rheumatoid arthritis
disease activity