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Biological Evaluation of Oral Care Products Using 3D Tissue-Engineered In Vitro Models of Plaque-Induced Gingivitis.

Emilia BarkerLina AlQobalyZahab ShaikhKirsty FranklinJohanna ThurlowBehfar MoghaddamJonathan PrattenZahab N Shaikh
Published in: Dentistry journal (2024)
The inflamed 3D oral mucosal model developed in this study has the potential to be used as a suitable in vitro model for testing the biocompatibility, anti-inflammatory, and anti-bacterial properties of oral care products including mouthwashes and toothpastes. The results of this study indicate that the chlorhexidine mouthwash has both anti-bacterial and cytotoxic effects on the 3D oral mucosal model. Hyaluronic-acid-containing toothpaste has significant anti-bacterial and anti-inflammatory effects on the 3D oral mucosal model.
Keyphrases
  • anti inflammatory
  • healthcare
  • hyaluronic acid
  • coronary artery disease
  • pain management
  • risk assessment
  • oxidative stress
  • chronic pain
  • diabetic rats