The effect of chronic exposure to metformin in a new type-2 diabetic NONcNZO10/LtJ mouse model of stroke.
Rashmi KumariLisa WillingScot R KimballIan A SimpsonPublished in: Pharmacological reports : PR (2022)
The study suggests that the prolonged effect of metformin-induced euglycemia promoted the microglial activation, reduced neuronal cell death, and improved the overall survival following stroke, without any change in infarct size.
Keyphrases
- cell death
- atrial fibrillation
- mouse model
- cerebral ischemia
- type diabetes
- high glucose
- diabetic rats
- inflammatory response
- acute myocardial infarction
- neuropathic pain
- oxidative stress
- coronary artery disease
- endothelial cells
- spinal cord
- free survival
- blood brain barrier
- cell cycle arrest
- subarachnoid hemorrhage
- left ventricular