Extracellular HMGB-1 activates inflammatory signaling in tendon cells and tissues.

Chuanxin ZhangXinfeng GuGuangyi ZhaoWang WangJiahua ShaoJun ZhuTing YuanJiuyi SunDaibang NieYiqin Zhou

Published in: Therapeutic advances in chronic disease (2020)

Collectively, these results confirm that HMGB-1 plays key roles in the induction of tendinopathy. Our findings improve the understanding of the molecular and cellular mechanisms during tendinopathy development, and provide essential information for potential targeted treatments of tendinopathy.

Keyphrases

rotator cuff
platelet rich plasma
induced apoptosis
cell cycle arrest
oxidative stress
gene expression
cancer therapy
cell death
endoplasmic reticulum stress
healthcare
risk assessment
human health
drug delivery
social media
cell proliferation
pi k akt