HCV cirrhotic patients treated with direct-acting antivirals: Detection of tubular dysfunction and resolution after viral clearance.
Elisa BiliottiDonatella PalazzoFrancesca TintiMaria Domenica D'AlessandroRozenn EsvanRaffaella LabriolaAndrea CappoliIlaria UmbroLorenzo VolpicelliAlessandra BachetoniErica VillaAnna Paola MitterhoferPaola RucciGloria TalianiPublished in: Liver international : official journal of the International Association for the Study of the Liver (2021)
Tubular dysfunction is an unrecognized feature of HCV-related kidney disease in cirrhotic patients and its presence should be primarily investigated in subjects with glomerular damage, diabetes and hypertension, despite normal e-GFR. Tubular dysfunction resolves in the majority of cases after HCV clearance; however, it may persist after antiviral treatment and further studies should evaluate its long-term impact on kidney function.
Keyphrases
- hepatitis c virus
- oxidative stress
- high glucose
- end stage renal disease
- human immunodeficiency virus
- chronic kidney disease
- blood pressure
- ejection fraction
- newly diagnosed
- type diabetes
- cardiovascular disease
- machine learning
- sars cov
- prognostic factors
- deep learning
- endothelial cells
- patient reported outcomes
- metabolic syndrome
- adipose tissue
- single molecule
- high resolution
- insulin resistance
- arterial hypertension
- loop mediated isothermal amplification
- antiretroviral therapy
- high speed