Hypertensive disorders of pregnancy and cardiovascular disease risk: a Mendelian randomisation study.

Lena Tschiderer Yvonne T van der Schouw Stephen BurgessKitty W M BloemenkampLisa SeekircherPeter WilleitCharlotte Onland-MoretSanne A E Peters

Published in: Heart (British Cardiac Society) (2024)

Genetic liability to HDPs is associated with higher CVD risk, lower blood pressure levels and earlier hypertension diagnosis. Our study suggests similar findings in ever pregnant women, nulligravidae and men, implying biological mechanisms relating to HDPs are causally related to CVD risk.

Keyphrases

blood pressure
pregnant women
cardiovascular disease
type diabetes
gene expression
hypertensive patients
genome wide
preterm birth
pregnancy outcomes
skeletal muscle
copy number
blood glucose