Longitudinal monitoring by next-generation sequencing of plasma cell-free DNA in ALK rearranged NSCLC patients treated with ALK tyrosine kinase inhibitors.

Minsuk KwonBo Mi KuSteve OlsenSehhoon ParkMartina LefterovaJustin OdegaardHyun-Ae JungJong-Mu SunSe-Hoon LeeJin Seok AhnKeunchil ParkMyung-Ju Ahn

Published in: Cancer medicine (2022)

cfDNA-NGS facilitates detection of ALK fusions and resistance mutations, assessment of prognosis, and monitoring dynamic changes of genomic alterations in ALK+ NSCLC treated with ALK-TKI.

Keyphrases

advanced non small cell lung cancer
epidermal growth factor receptor
small cell lung cancer
copy number
gene expression
loop mediated isothermal amplification
sensitive detection
brain metastases
circulating tumor cells