Intrauterine delivery of subunit vaccines induces a systemic and mucosal immune response in rabbits.

Jonathan Alexander PasternakGlenn HamonicNikki M ForsbergColette L WhelerMichael K DyckHeather L Wilson

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2017)

The results of this study provide proof of principle that the uterus can be used as an induction site for subunit vaccination and that vaccine formulation with appropriate adjuvants can trigger both systemic and mucosal immunity when administered IM or into the uterine lumen.

Keyphrases

drug delivery
immune response
ulcerative colitis
protein kinase
dendritic cells
toll like receptor