Addition of a 161-SNP polygenic risk score to family history-based risk prediction: impact on clinical management in non-BRCA1/2 breast cancer families.

Inge M M LakemanFlorentine S HilbersMar Rodríguez-GirondoAndrew LeeMaaike P G VreeswijkAntoinette HollestelleCaroline SeynaeveHanne Meijers-HeijboerJan C OosterwijkNicoline HoogerbruggeEdith OlahHans F A VasenChristi J van AsperenPeter Devilee

Published in: Journal of medical genetics (2019)

Our results support the application of the PRS in risk prediction and clinical management of women from genetically unexplained breast cancer families.

Keyphrases

breast cancer risk
polycystic ovary syndrome
genome wide
gene expression
metabolic syndrome
pregnant women
dna methylation
childhood cancer