B7-H4 is highly expressed in aggressive Epstein-Barr virus positive diffuse large B-cell lymphoma and inhibits apoptosis through upregulating Erk1/2 and Akt signalling pathways.

Ying JiangGangli CaiJun LinJing ZhangZhilei BoYing LiChun WangYin Tong

Published in: Infectious agents and cancer (2019)

Our study reveals a critical role of B7-H4 in EBV+DLBCL development by regulating cell survival and apoptosis through the Erk and Akt signalling pathways. Targetting B7-H4 may be promising in the therapy of EBV+DLBCL.

Keyphrases

diffuse large b cell lymphoma
epstein barr virus
signaling pathway
cell proliferation
cell cycle arrest
pi k akt
endoplasmic reticulum stress
oxidative stress
cell death
stem cells
cell therapy