Aluminum Nanocrystals: A Sustainable Substrate for Quantitative SERS-Based DNA Detection.
Shu TianOara NeumannMichael J McClainXiao YangLinan ZhouChao ZhangPeter J NordlanderNaomi J HalasPublished in: Nano letters (2017)
Since its discovery in the 1970s, surface-enhanced Raman scattering (SERS) has been primarily associated with substrates composed of nanostructured noble metals. Here we investigate chemically synthesized nanocrystal aggregates of aluminum, an inexpensive, highly abundant, and sustainable metal, as SERS substrates. Al nanocrystal aggregates are capable of substantial near-infrared SERS enhancements, similar to Au nanoparticles. The intrinsic nanoscale surface oxide of Al nanocrystals supports molecule-substrate interactions that differ dramatically from noble metal substrates. The preferential affinity of the single-stranded DNA (ssDNA) phosphate backbone for the Al oxide surface preserves both the spectral features and nucleic acid cross sections relative to conventional Raman spectroscopy, enabling quantitative ssDNA detection and analysis.
Keyphrases
- raman spectroscopy
- nucleic acid
- sensitive detection
- label free
- loop mediated isothermal amplification
- gold nanoparticles
- circulating tumor
- high resolution
- single molecule
- cell free
- oxide nanoparticles
- room temperature
- small molecule
- real time pcr
- quantum dots
- optical coherence tomography
- high throughput
- energy transfer
- atomic force microscopy
- magnetic resonance imaging
- amino acid
- mass spectrometry
- risk assessment
- computed tomography
- drinking water
- high speed
- heavy metals
- single cell
- capillary electrophoresis