Regional modulation of toll-like receptor signaling pathway genes in acute epididymitis in mice.
Alexandre D AndradePriscila G C AlmeidaNoemia A P MarianiNatalia C M SantosIsabela A CamargoPoliana V MartiniHelio KushimaDingding AiMaria Christina W AvellarAndreas MeinhardtChristiane PleugerErick J R SilvaPublished in: Andrology (2024)
The dynamic modulation of TLR4 and TLR2/TLR6 signaling pathways gene expression during epididymitis indicates bacterial-derived antigens elicit an increased tissue sensitivity to combat microbial infection in a spatial manner in the epididymis. Differential activation of TLR-associated signaling pathways may contribute to fine-tuning inflammatory responses along the epididymis.
Keyphrases
- toll like receptor
- signaling pathway
- inflammatory response
- nuclear factor
- gene expression
- immune response
- pi k akt
- epithelial mesenchymal transition
- induced apoptosis
- dna methylation
- microbial community
- dendritic cells
- liver failure
- air pollution
- type diabetes
- drug induced
- cell proliferation
- adipose tissue
- genome wide
- insulin resistance
- high fat diet induced
- skeletal muscle
- transcription factor
- acute respiratory distress syndrome
- genome wide analysis